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Literature summary for 3.4.21.72 extracted from

  • Mistry, D.V.; Stockley, R.A.
    The cleavage specificity of an IgA1 protease from Haemophilus influenzae (2011), Virulence, 2, 103-110.
    View publication on PubMed
Search for more literature for 3.4.21.72

Cloned(Commentary)

Cloned (Comment) Organism
gene iga, DNA and amino acid sequence determination and analysis Haemophilus influenzae

Inhibitors

Inhibitors Comment Organism Structure
additional information no inhibition by natural protease inhibitors SLPI, alpha-1-antitrypsin, cathepsin G and cystatin C, and by synthetic protease inhibitors Tos-Lys-chloromethylketone, and ZD0892 Haemophilus influenzae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
human IgA1 + H2O Haemophilus influenzae unique cleavage specificity of the NTHI IgA1 protease ?
-
 ?

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae P44969 non-typeable Haemophilus influenzae, NTHI, gene iga
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Source Tissue

Source Tissue Comment Organism Textmining
additional information NTHI is a Gram-negative coccobacillus, which colonizes the human upper respiratory tract as part of the normal flora Haemophilus influenzae
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
human IgA1 + H2O unique cleavage specificity of the NTHI IgA1 protease Haemophilus influenzae ?
-
 ?
human IgA1 + H2O deglycosylated human IgA1, the IgA1 protease cleaves two peptide bonds within the human IgA1 hinge region at replicate sequences, cleavage of human IgA1 produces two different sized Fc fragments with N-terminal sequence Thr-Pro-Ser-Pro-Ser Haemophilus influenzae ?
-
 ?
additional information no activity with human IgA2 Haemophilus influenzae ?
-
 ?

Synonyms

Synonyms Comment Organism
IgA1 protease
-
 Haemophilus influenzae