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Literature summary for 3.4.21.72 extracted from
- Characterization of igaB, a second immunoglobulin A1 protease gene in nontypeable Haemophilus influenzae (2006), Infect. Immun., 74, 5860-5870.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene igaB, DNA and amino acid sequence determination and analysis, genetic organization of the igaB locus, overview | Haemophilus influenzae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of igaB mutants and igaA/igaB double mutants of strain 11P6H | Haemophilus influenzae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| human immunoglobulin A1 + H2O | Haemophilus influenzae | - |
? | - |
? |  |
| additional information | Haemophilus influenzae | the type 2 IgA1 protease is a potential virulence factor in Haemophilus influenzae, the igaB encoded enzyme is the primary mediator of IgA1 protease activity in strain 11P6H, not the type 1 IgA1 protease encoded by igaA, IgA1 proteases are classified as type 1 or type 2 based on the specific site of enzymatic cleavage in the hinge region of the IgA1 molecule | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Haemophilus influenzae | - |
strain 11P6H, a strain isolated from the sputum of a patient with chronic obstructive pulmonary disease, experiencing an exacerbation, gene igaB | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | distribution of igaB among clinical isolates of nontypeable Haemophilus influenzae, overview | Haemophilus influenzae | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Haemophilus influenzae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| human immunoglobulin A1 + H2O | - |
Haemophilus influenzae | ? | - |
? | |
| additional information | the type 2 IgA1 protease is a potential virulence factor in Haemophilus influenzae, the igaB encoded enzyme is the primary mediator of IgA1 protease activity in strain 11P6H, not the type 1 IgA1 protease encoded by igaA, IgA1 proteases are classified as type 1 or type 2 based on the specific site of enzymatic cleavage in the hinge region of the IgA1 molecule | Haemophilus influenzae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| IgA1 protease | - |
Haemophilus influenzae |
| immunoglobulin A1 protease | - |
Haemophilus influenzae |
| type 2 IgA1 protease | - |
Haemophilus influenzae |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Haemophilus influenzae |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Haemophilus influenzae |
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