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Literature summary for 3.4.21.72 extracted from

  • Plaut, A.G.; Bachovchin, W.W.
    IgA-specific prolyl endopeptidases: serine type (1994), Methods Enzymol., 244, 137-151.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
-
Haemophilus influenzae
-
Neisseria gonorrhoeae

Inhibitors

Inhibitors Comment Organism Structure
3,4-dichloroisocoumarin
-
Ureaplasma urealyticum
diisopropyl fluorophosphate
-
Haemophilus influenzae
diisopropyl fluorophosphate
-
Neisseria gonorrhoeae
diisopropyl fluorophosphate
-
Ureaplasma urealyticum
Peptide prolyl boronic acids
-
Haemophilus influenzae
Peptide prolyl boronic acids
-
Neisseria gonorrhoeae

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Haemophilus influenzae
-
-
extracellular
-
Neisseria gonorrhoeae
-
-
extracellular
-
Neisseria meningitidis
-
-
extracellular
-
Streptococcus pneumoniae
-
-
extracellular
-
Ureaplasma urealyticum
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
immunoglobulin A + H2O Haemophilus influenzae IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
?
immunoglobulin A + H2O Neisseria gonorrhoeae IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
?
immunoglobulin A + H2O Neisseria meningitidis IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
?
immunoglobulin A + H2O Streptococcus pneumoniae IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
?
immunoglobulin A + H2O Ureaplasma urealyticum IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process ?
-
?

Organism

Organism UniProt Comment Textmining
Haemophilus influenzae
-
-
-
Neisseria gonorrhoeae
-
-
-
Neisseria meningitidis
-
-
-
Streptococcus pneumoniae
-
-
-
Ureaplasma urealyticum
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
culture medium
-
Haemophilus influenzae
-
culture medium
-
Neisseria gonorrhoeae
-
culture medium
-
Neisseria meningitidis
-
culture medium
-
Streptococcus pneumoniae
-
culture medium
-
Ureaplasma urealyticum
-

Storage Stability

Storage Stability Organism
4°C, slow loss of activity Haemophilus influenzae
4°C, slow loss of activity Neisseria gonorrhoeae
4°C, slow loss of activity Neisseria meningitidis
4°C, slow loss of activity Streptococcus pneumoniae
4°C, slow loss of activity Ureaplasma urealyticum
Frozen enzyme is stable for at least 1 year Haemophilus influenzae
Frozen enzyme is stable for at least 1 year Neisseria gonorrhoeae
Frozen enzyme is stable for at least 1 year Neisseria meningitidis
Frozen enzyme is stable for at least 1 year Streptococcus pneumoniae
Frozen enzyme is stable for at least 1 year Ureaplasma urealyticum

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Immunoglobulin A + H2O
-
Neisseria gonorrhoeae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O
-
Neisseria meningitidis immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O
-
Streptococcus pneumoniae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O
-
Ureaplasma urealyticum immunoglobulin Fabalpha + immunoglobulin Fc
-
?
Immunoglobulin A + H2O Haemophilus influenzae enzyme has at least 2 cleavage types. Serogroups, type 1 in serotypes a, b, d, f. Type 2 in c and e Haemophilus influenzae immunoglobulin Fabalpha + immunoglobulin Fc
-
?
immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Haemophilus influenzae ?
-
?
immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Neisseria gonorrhoeae ?
-
?
immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Neisseria meningitidis ?
-
?
immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Streptococcus pneumoniae ?
-
?
immunoglobulin A + H2O IgA hydrolysis may allow the microbes to circumvent immunity, or possibly even recruit antibodies or their fragments as a step in the infectious process Ureaplasma urealyticum ?
-
?