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Literature summary for 3.4.21.71 extracted from

  • Bonnart, C.; Deraison, C.; Lacroix, M.; Uchida, Y.; Besson, C.; Robin, A.; Briot, A.; Gonthier, M.; Lamant, L.; Dubus, P.; Monsarrat, B.; Hovnanian, A.
    Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing (2010), J. Clin. Invest., 120, 871-882.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
kallikrein 5 kallikrein 5 leads to an elastolytic activity increase of 4times compared with the basal activity level of pro-ELA2 Mus musculus
kallikrein 5 kallikrein 5 leads to an elastolytic activity increase of 4times compared with the basal activity level of pro-elastase 2 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
secretory leukoprotease inhibitor
-
Homo sapiens
secretory leukoprotease inhibitor
-
Mus musculus
skin-derived antileukoprotease
-
Homo sapiens
skin-derived antileukoprotease
-
Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(pro)-filaggrin + H2O Mus musculus direct degradation ?
-
?
(pro)-filaggrin + H2O Homo sapiens direct degradation ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
epidermis localized to keratohyalin granules Mus musculus
-
epidermis localized to keratohyalin granules Homo sapiens
-
keratinocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(pro)-filaggrin + H2O direct degradation Mus musculus ?
-
?
(pro)-filaggrin + H2O direct degradation Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
ELA2
-
Mus musculus
ELA2
-
Homo sapiens
Elastase 2
-
Mus musculus
Elastase 2
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000143
-
skin-derived antileukoprotease pH and temperature not specified in the publication Homo sapiens
0.0000299
-
secretory leukoprotease inhibitor pH and temperature not specified in the publication Homo sapiens

General Information

General Information Comment Organism
physiological function elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome Homo sapiens
physiological function elastase 2 impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing. The enzyme is a major protease driving the pathogenesis of Netherton syndrome. Transgenic elastase 2 mice display an ichthyotic phenotype Mus musculus