Inhibitors | Comment | Organism | Structure |
---|---|---|---|
alpha2-antiplasmin | inhibits proteolysis of rADAMTS13 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADAMTS13 + H2O | Homo sapiens | inactivation | ? | - |
? | |
additional information | Homo sapiens | plasmin selectively cleaves arginyl-X and lysyl-X peptide bonds in many target proteins | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADAMTS13 + H2O | inactivation | Homo sapiens | ? | - |
? | |
additional information | plasmin selectively cleaves arginyl-X and lysyl-X peptide bonds in many target proteins | Homo sapiens | ? | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura, propagation by deficiency of alpha2-antiplasmin function in acute-phase, but not remission-phase plasma, overview. ADAMTS13 is truncated at the C-terminus during the acute phase | Homo sapiens |