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Literature summary for 3.4.21.7 extracted from

  • Feys, H.B.; Vandeputte, N.; Palla, R.; Peyvandi, F.; Peerlinck, K.; Deckmyn, H.; Lijnen, H.R.; Vanhoorelbeke, K.
    Inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura (2010), J. Thromb. Haemost., 8, 2053-2062.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
alpha2-antiplasmin inhibits proteolysis of rADAMTS13 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADAMTS13 + H2O Homo sapiens inactivation ?
-
?
additional information Homo sapiens plasmin selectively cleaves arginyl-X and lysyl-X peptide bonds in many target proteins ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADAMTS13 + H2O inactivation Homo sapiens ?
-
?
additional information plasmin selectively cleaves arginyl-X and lysyl-X peptide bonds in many target proteins Homo sapiens ?
-
?

General Information

General Information Comment Organism
physiological function inactivation of ADAMTS13 by plasmin as a potential cause of thrombotic thrombocytopenic purpura, propagation by deficiency of alpha2-antiplasmin function in acute-phase, but not remission-phase plasma, overview. ADAMTS13 is truncated at the C-terminus during the acute phase Homo sapiens