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Literature summary for 3.4.21.7 extracted from

  • Kanno, Y.; Ishisaki, A.; Kawashita, E.; Chosa, N.; Nakajima, K.; Nishihara, T.; Toyoshima, K.; Okada, K.; Ueshima, S.; Matsushita, K.; Matsuo, O.; Matsuno, H.
    Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function (2011), J. Biol. Chem., 286, 8952-8960.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.7

Inhibitors

Inhibitors Comment Organism Structure
alpha2-antiplasmin
-
 Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
bone marrow cell
-
 Mus musculus
-
commercial preparation
-
 Mus musculus
-
RAW-264.7 cell
-
 Mus musculus
-

General Information

General Information Comment Organism
physiological function plasmin stimulates phosphorylation of ERK1/2 and p38 MAPK. Plasminogen/plasmin modulates bone metabolism by regulating the osteoblast and osteoclast function. Exogenous plasmin clearly induces the osteoprotegerin expression in plasminogen-deficient osteoblasts. Plasmin activates JNK, but the inhibition of JNK does not attenuate plasmin-induced osteoprotegerin expression Mus musculus