Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
artery | vessel wall | Homo sapiens | - |
monocyte | - |
Homo sapiens | - |
additional information | plasmin is abundant in human atherosclerotic lesions, where it colocalizes with dendritic cells | Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | plasmin triggers chemotaxis of monocyte-derived dendritic cells through an Akt2-dependent pathway and promotes a T-helper type-1 response. Plasmin requires the annexin A2 heterotetramer for chemotactic signaling. Activation of Akt2 leads to extracellular signal-regulated kinase 1/2 activation and the chemotactic response. Plasmin elicits a time-dependent actin polymerization and triggers rapid activation of Akt and mitogen-activated protein kinases, followed by phosphorylation of the regulatory myosin light chain and chemotaxis. In dendritic cells, plasmin activates exclusively Akt2 via a p38 mitogen-activated protein kinase-dependent pathway, not Akt1 and Akt3. Plasmin-stimulated dendritic cells induce polarization of CD4+ T cells toward the interferon-gamma--producing, proinflammatory Th1 phenotype | Homo sapiens |