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Literature summary for 3.4.21.7 extracted from

  • Gray, K.; Ellis, V.
    Activation of pro-BDNF by the pericellular serine protease plasmin (2008), FEBS Lett., 582, 907-910.
    View publication on PubMed
Search for more literature for 3.4.21.7

Activating Compound

Activating Compound Comment Organism Structure
additional information activation of a low concentration of plasminogen by cell-associated plasminogen activators produces sufficient active plasmin to rapidly and efficiently process pro-brain-derived neurotrophic factor in the pericellular environment Homo sapiens

Application

Application Comment Organism
medicine processing of pro-brain-derived neurotrophic factor by plasmin stimulates neurite outgrowth on TrkB-transfected PC-12 cells to a similar extent than mature wild-type brain-derived neurotrophic factor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
additional information in PC-3 cells, processing of pro-brain-derived neurotrophic factor by plasmin occurs in the pericellular environment Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pro-brain-derived neurotrophic factor + H2O plasmin is a specific and efficient activator of pro-brain-derived neurotrophic factor. The pro-form is rapidly processed to an 18 kDa fragment at a low concentration of plasmin. This C-terminal fragment is equivalent in size to the furin-processed, mature form of wild-type brain-derived neurotrophic factor. The proteolytic cleavage site is Arg125-Val126, within the consensus furin-cleavage motif Homo sapiens ?
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