Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fibroblast | rheumatoid synovial fibroblasts | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | activated protein C is a natural anticoagulant that exerts anti-inflammatory and cytoprotective effects in various diseases via endothelial protein C receptor and proteinase-activated receptor-mediated pathways. Activated protein C inhibits proliferation and tumor necrosis factor alpha-stimulated activation of p38, c-Jun NH2-terminal kinase, and Akt in rheumatoid synovial fibroblasts. The enzyme induces the phosphorylation of extracellular signal-regulated protein kinase and enhances expression of p21 and p27 in a dose-dependent manner in rheumatoid synovial fibroblasts. The enzyme stimulates proliferation of normal human dermal fibroblasts by up to 60%, but robustly downregulates proliferation of rheumatoid synovial fibroblasts | Homo sapiens |