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Literature summary for 3.4.21.69 extracted from

  • Julovi, S.M.; Shen, K.; Mckelvey, K.; Minhas, N.; March, L.; Jackson, C.J.
    Activated protein C inhibits proliferation and tumor necrosis factor alpha-stimulated activation of p38, c-Jun NH2-terminal kinase (JNK) and Akt in rheumatoid synovial fibroblasts (2013), Mol. Med., 19, 324-331.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
fibroblast rheumatoid synovial fibroblasts Homo sapiens
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Synonyms

Synonyms Comment Organism
Activated protein C
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Homo sapiens
APC
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Homo sapiens

General Information

General Information Comment Organism
physiological function activated protein C is a natural anticoagulant that exerts anti-inflammatory and cytoprotective effects in various diseases via endothelial protein C receptor and proteinase-activated receptor-mediated pathways. Activated protein C inhibits proliferation and tumor necrosis factor alpha-stimulated activation of p38, c-Jun NH2-terminal kinase, and Akt in rheumatoid synovial fibroblasts. The enzyme induces the phosphorylation of extracellular signal-regulated protein kinase and enhances expression of p21 and p27 in a dose-dependent manner in rheumatoid synovial fibroblasts. The enzyme stimulates proliferation of normal human dermal fibroblasts by up to 60%, but robustly downregulates proliferation of rheumatoid synovial fibroblasts Homo sapiens