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Literature summary for 3.4.21.69 extracted from

  • Lee, Y.J.; Jeong, J.K.; Seol, J.W.; Xue, M.; Jackson, C.; Park, S.Y.
    Activated protein C differentially regulates both viability and differentiation of osteoblasts mediated by bisphosphonates (2013), Exp. Mol. Med., 45, e9.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.69

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MG-63 cell
-
 Homo sapiens
-
osteoblastoma cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Activated protein C
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 Homo sapiens
APC
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function the activated protein C plays a central role in physiological anticoagulation, and has potent anti-inflammatory mediator and cytoprotective properties. Activated protein C is a cytoprotective anticoagulant that can promote cutaneous healing. The enzyme favorably regulates MG63 viability and differentiation toward bone growth. Bisphosphonates alendronate, zoledronate or pamidronate induce MG-63 cell death in a dose- and time-dependent manner. Pamidronate- and zoledronate-related cell death is prevented by the enzyme treatment, but cell death induced by alendronate is accelerated by the enzyme. The enzyme induces MG-63 cell differentiation that is enhanced by alendronate, but inhibited by pamidronate or zoledronate. Endothelial protein C receptor is expressed by MG-63 cells and mediates the protective effect of the enzyme on zoledronate-induced viability. Expression of type 1 collagen and endothelial protein C receptor is induced by activated protein C treatment in MG-63 cells Homo sapiens