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Literature summary for 3.4.21.69 extracted from

  • Li, B.; Yu, D.; Xu, Z.
    Activated protein C inhibits amyloid beta production via promoting expression of ADAM-10 (2014), Brain Res., 1545, 35-44.
    View publication on PubMed
Search for more literature for 3.4.21.69

Application

Application Comment Organism
medicine the enzyme might have therappeutic potential in treatment of Alzheimer's disease Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface inactive enzyme Homo sapiens 9986
-
extracellular active enzyme Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification inactive plasma zymogen protein C is activated by proteolysis through the thrombin-thrmbomdulin complex on the vascular endothelial cell surface Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-
endothelial cell inactive enzyme Homo sapiens
-
SH-SY5Y cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Activated protein C
-
 Homo sapiens
APC
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function activated protein C is an important factor in the anticoagulant system. It also regulates amyloid beta secretion by shifting amyloid beta precursor protein processing from the amyloidogenic pathway toward the nonamyloidogenic pathway. ADAM-10 expression is increased by the enzyme and inhibits amyloid beta secretion by stimulating activity of alpha-secretase, expression of presenilin-1 is not influenced by the enzyme in SH-SY5Ycells Homo sapiens