Inhibitors | Comment | Organism | Structure |
---|---|---|---|
DAN-Glu-Gly-Arg-CMK | dansyl-glutamyl-glycyl-arginyl-chloromethylketone, blocks the enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | APC activity is measured using the commercial chromogenic substrate Spectrozyme PCa | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | the procoagulant role of the protein C pathway may have important implications for the regulation of TF- and TFPI-dependent biologic responses and for fine tuning of the hemostatic balance in the vascular system | Homo sapiens |
additional information | a TFPI Lys86Ala mutation between the Kunitz 1 and 2 domains eliminates both cleavage and the enhanced TF activity in response to APC in overexpression studies | Homo sapiens |
physiological function | activated protein C upregulates TF activity by endothelial cell protein C receptordependent shedding of the Kunitz 1 domain from membrane-associated TFPI. Exogenous or endogenously generated APC leads to increased TF-dependent factor Xa activity. Induction requires APC's proteolytic activity and binding to endothelial cell protein C receptor but not protease activated receptors, mechanism, overview. APC does not affect total TF antigen expression or the availability of anionic phospholipids on the apical cell membrane | Homo sapiens |