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Literature summary for 3.4.21.69 extracted from

  • Guitton, C.; Cottereau, A.; Gerard, N.; Quillard, T.; Chauveau, A.; Devalliere, J.; Tonnerre, P.; Charreau, B.
    Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells: implication of EPCR, noncanonical NF-kappaB, and ERK1/2 MAP kinases (2011), Am. J. Physiol. Cell Physiol., 300, C833-C842.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens APC upregulates TNF receptor-associated factor 2, TRAF2, and phosphorylates NF-kappaB p65 at Ser276 and Ser536 independently of IkappaB degradation, real-time quantitative PCR analysis, overview ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation recombinant APC Homo sapiens
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vascular endothelial cell HUVEC Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information APC upregulates TNF receptor-associated factor 2, TRAF2, and phosphorylates NF-kappaB p65 at Ser276 and Ser536 independently of IkappaB degradation, real-time quantitative PCR analysis, overview Homo sapiens ?
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 ?

Synonyms

Synonyms Comment Organism
Activated protein C
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 Homo sapiens
APC
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 Homo sapiens

General Information

General Information Comment Organism
physiological function activated protein C is a natural anticoagulant protease that displays cytoprotective and antiinflammatory activities and has been demonstrated to reduce mortality of patients with severe sepsis. Protective cross talk between activated protein C and TNF signaling in vascular endothelial cells, overview. APC signaling causes a moderate but significant induction of cell adhesion molecules including VCAM-1 at mRNA and protein levels. Activation of the noncanonical NF-kappaB and ERK1/2 are both pivotal to APC signaling leading to VCAM-1 expression, PAR1 and EPCR equally mediate APC signaling that triggers VCAM-1 expression. APC upregulates TNF receptor-associated factor 2, TRAF2, and phosphorylates NF-kappaB p65 at Ser276 and Ser536 independently of IkappaB degradation, and it shows a regulatory effect on VCAM-1 expression, detailed overview. Ability of APC to activate ERK1/2 in resting cells and to enhance ERK activation in TNF-treated cells, activated ERK1/2 MAPK serves as an antiinflammatory signal in endothelial cells Homo sapiens