Literature summary for 3.4.21.69 extracted from

Toltl, L.J.; Beaudin, S.; Liaw, P.C.; Liaw, P.C.
Activated protein C up-regulates IL-10 and inhibits tissue factor in blood monocytes (2008), J. Immunol., 181, 2165-2173.

Search for more literature for 3.4.21.69

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	p38 MAPK activation is required for recombinant activated protein C-mediated up-regulation of interleukin-10. Endothelial protein C receptor and protease-activated receptor-1 are required for the upregulation of interleukin-10 by recombinant activated protein C, whereas JRK 1495, JRK 1535, or ATAP-2 have no effect	Homo sapiens

Application

Application	Comment	Organism
medicine	recombinant activated protein C-mediated upregulation of interleukin-10 reduces tissue factor in circulating monocytes. Part of the protective effect of recombinant activated protein C therapy may reflect the ability of recombinant activated protein C to dampen the proinflammatory and procoagulant potential of activated monocytes	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Phe-Pro-Arg-chloromethylketone	inhibits the active site of recombinant activated protein C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	treatment of lipopolysaccharide-stimulated blood monocytes with recombinant activated protein C results in an upregulation of interleukin-10 protein production and mRNA synthesis and a downregulation of tissue factor Ag and activity levels. Serine protease activity is required for the upregulation of interleukin-10 by recombinant activated protein C	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Activated protein C	-	Homo sapiens

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Release 2023.1 (January 2023)