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Literature summary for 3.4.21.69 extracted from

  • Slofstra, S.H.; ten Cate, H.; Spek, C.A.
    Signal transduction induced by activated protein C: no role in protection against sepsis? (2006), Trends Mol. Med., 12, 374-381.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Homo sapiens 5829
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Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ the activated enzyme induces cytsolic Ca2+ signals, mechanism Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the activated enzyme induces signal transduction in an endothelial protein C receptor- or PAR1-dependent manner involved in apoptosis, microcirculation, and vascular permeability, the activated enzyme plays an important role in sepsis, but does not protect against sepsis, effects of long time treatment, overview, the activated enzyme induces expression of monocyte chemoattractant protein-1, MCP-1, in endothelial cells, overview ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
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endothelium
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the activated enzyme induces signal transduction in an endothelial protein C receptor- or PAR1-dependent manner involved in apoptosis, microcirculation, and vascular permeability, the activated enzyme plays an important role in sepsis, but does not protect against sepsis, effects of long time treatment, overview, the activated enzyme induces expression of monocyte chemoattractant protein-1, MCP-1, in endothelial cells, overview Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
anticoagulant activated protein C
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Homo sapiens