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Literature summary for 3.4.21.69 extracted from

  • Malm, K.; Arnljots, B.; Persson, I.M.; Dahlbaeck, B.
    Antithrombotic and anticoagulant effects of wild type and Gla-domain mutated human activated protein C in rats (2007), Thromb. Res., 120, 531-539.
    View publication on PubMed
Search for more literature for 3.4.21.69

Protein Variants

Protein Variants Comment Organism
H10Q/S11G/S12N/D23S/Q32E/N33D/H44Y naturally occuring Gla-domain mutant, the mutant enzyme shows a higher anticoagulant effect compared to the wild-type enzyme, the combination with the B148 mutation in the serine protease domain even enhances the effect, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the recombinant enzyme shows antithrombotic and anticoagulant effects in a rat model of arterial thrombosis, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 blood clotting activity of wild-type and mutant enzymes in vitro in rat plasma and in vivo in the rat model, overview Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the recombinant enzyme shows antithrombotic and anticoagulant effects in a rat model of arterial thrombosis, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Activated protein C
-
 Homo sapiens
hAPC
-
 Homo sapiens