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Literature summary for 3.4.21.69 extracted from
- Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va (2008), J. Biol. Chem., 283, 6648-6655.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| prothrombin | addition results in a 10fold decreased inactivation rate in absence and 4fold in presence of protein S, overview | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics with wild-type and mutant factors Va | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| active factor Va + H2O | Homo sapiens | proteolytic inactivation | inactive factor V heavy chain + peptide fragment 307-709 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| active factor Va + H2O | proteolytic inactivation | Homo sapiens | inactive factor V heavy chain + peptide fragment 307-709 | - |
? | |
| active factor Va + H2O | proteolytic inactivation, cleavage at Arg306 and Arg506 | Homo sapiens | inactive factor V heavy chain + peptide fragment 307-709 | - |
? | |
| active factor Va mutant R306Q + H2O | proteolytic inactivation, cleavage at Arg506 | Homo sapiens | ? | - |
? | |
| active factor Va mutant R506Q + H2O | proteolytic inactivation, cleavage at Arg306 | Homo sapiens | ? | - |
? | |
| S2366 + H2O | a chromogenic substrate | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Activated protein C | - |
Homo sapiens |
| APC | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.7 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| protein S | stimulates, partially prevents the inhibition of the enzyme by prothrombin | Homo sapiens |
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Release 2023.1 (January 2023)
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