Literature summary for 3.4.21.69 extracted from

Baltch, A.L.; Bopp, L.H.; Ritz, W.J.; Michelsen, P.B.; Yan, S.B.; Um, S.; Smith, R.P.
Effect of recombinant human activated protein C on the bactericidal activity of human monocytes and modulation of pro-inflammatory cytokines in the presence of antimicrobial agents (2007), J. Antimicrob. Chemother., 59, 1177-1181.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	recombinant activated protein C enhances intracellular antibacterial activity, against Escherichia coli strain ATCC 25922, in presence of antibiotics, e.g. levofloxacin or ampicillin, but has no antibacterial effects without antibiotics, while it decreases the production of cytokines, such as TNF-alpha, IL-1beta and interleukin-6, but not interleukin-8, by monocytes	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	recombinant activated protein C enhances intracellular antibacterial activity, against Escherichia coli strain ATCC 25922, in presence of antibiotics, e.g. levofloxacin or ampicillin, but has no antibacterial effects without antibiotics, while it decreases the production of cytokines, such as TNF-alpha, IL-1beta and interleukin-6, but not interleukin-8, by monocytes	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
Activated protein C	-	Homo sapiens
rhAPC	-	Homo sapiens

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Release 2023.1 (January 2023)