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Literature summary for 3.4.21.69 extracted from

  • Beaulieu, L.M.; Church, F.C.
    Activated protein C promotes breast cancer cell migration through interactions with EPCR and PAR-1 (2007), Exp. Cell Res., 313, 677-687.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.69

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
active factor Va + H2O Homo sapiens proteolytic inactivation inactive factor V + ?
-
 ?
active factor VIIIa + H2O Homo sapiens proteolytic inactivation inactive factor VIII + domain B
-
 ?
additional information Homo sapiens the enzyme is a serine protease that regulates thrombin production through inactivation of blood coagulation factors Va and VIIIa, overview, treatment of breast cancer cells with exogenous active enzyme leads to increased invasion and chemotaxis, thereby not acting as a chemoattractant, but via endothelial protein C receptor and protease-activated receptor-1, PAR-1, receptor blocking b antibodies blocks the enzyme effects, overview, the enzyme does not increase cell division and proliferation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood circulation of inactive zymogen Homo sapiens
-
liver enzyme synthesis Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
active factor Va + H2O proteolytic inactivation Homo sapiens inactive factor V + ?
-
 ?
active factor VIIIa + H2O proteolytic inactivation Homo sapiens inactive factor VIII + domain B
-
 ?
additional information the enzyme is a serine protease that regulates thrombin production through inactivation of blood coagulation factors Va and VIIIa, overview, treatment of breast cancer cells with exogenous active enzyme leads to increased invasion and chemotaxis, thereby not acting as a chemoattractant, but via endothelial protein C receptor and protease-activated receptor-1, PAR-1, receptor blocking b antibodies blocks the enzyme effects, overview, the enzyme does not increase cell division and proliferation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Activated protein C
-
 Homo sapiens
APC
-
 Homo sapiens