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Literature summary for 3.4.21.69 extracted from

  • Khrenov, A.V.; Ananyeva, N.M.; Saenko, E.L.
    Role of the B domain in proteolytic inactivation of activated coagulation factor VIII by activated protein C and activated factor X (2006), Blood Coagul. Fibrinolysis, 17, 379-388.
    View publication on PubMed
Search for more literature for 3.4.21.69

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
active factor Va + H2O Homo sapiens proteolytic inactivation of the cofactor in the prothrombinase complex inactive factor V + ?
-
 ?
active factor VIII + H2O Homo sapiens activated protein C and activated factor X play a role in proteolytic inactivation of activated coagulation factor VIII involving the B domain, the inactivated substrate factor VIII is less efficient on blood clotting, overview inactive factor VIII + domain B
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
active factor Va + H2O proteolytic inactivation Homo sapiens inactive factor V + ?
-
 ?
active factor Va + H2O proteolytic inactivation of the cofactor in the prothrombinase complex Homo sapiens inactive factor V + ?
-
 ?
active factor VIII + H2O activated protein C and activated factor X play a role in proteolytic inactivation of activated coagulation factor VIII involving the B domain, the inactivated substrate factor VIII is less efficient on blood clotting, overview Homo sapiens inactive factor VIII + domain B
-
 ?
active factor VIIIa + H2O proteolytic inactivation, cleavage at Arg336 and Arg572 in domains A1 and A2, respectively Homo sapiens inactive factor VIII + domain B
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Homo sapiens

Cofactor

Cofactor Comment Organism Structure
protein S complexed witht the activated protein C, increases the activity 6-10fold Homo sapiens