Protein Variants | Comment | Organism |
---|---|---|
additional information | substitution of the autolysis loop of APC with the corresponding loop of trypsin has no influence on the proteolytic activity of the protease towards factor Va, however, this substitution increases the reactivity of APC with plasma inhibitors so that the mutant exhibits no anticoagulant activity in plasma, the mutant APC cannot interact with protein S as cofactor, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
active factor Va + H2O | Homo sapiens | proteolytic inactivation | inactive factor V + ? | - |
? | |
protease activated receptor 1 + H2O | Homo sapiens | APC can also bind to endothelial protein C receptor to activate protease activated receptor 1, PAR-1, thereby eliciting antiinflammatory and cytoprotective signaling responses in endothelial cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
active factor Va + H2O | proteolytic inactivation | Homo sapiens | inactive factor V + ? | - |
? | |
active factor Va + H2O | proteolytic inactivation, the autolysis loop of APC represents the active site, active site topology, the loop plays a critical role in restricting both the specificity and spatial environment of the active-site groove of APC, overview | Homo sapiens | inactive factor V + ? | - |
? | |
protease activated receptor 1 + H2O | APC can also bind to endothelial protein C receptor to activate protease activated receptor 1, PAR-1, thereby eliciting antiinflammatory and cytoprotective signaling responses in endothelial cells | Homo sapiens | ? | - |
? | |
protease activated receptor 1 + H2O | APC can also bind to endothelial protein C receptor to activate protease activated receptor 1, PAR-1, APC cleaves the PAR-1 exodomain with about 750fold lower catalytic efficiency than thrombin | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Activated protein C | - |
Homo sapiens |
APC | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
protein S | from human plasma, interacts with the autolysis loop of the enzyme | Homo sapiens |