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Literature summary for 3.4.21.69 extracted from
- Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase (1996), J. Biol. Chem., 271, 3982-3987.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Factor VIIIa + H2O | cleavage at two sites: at Arg336 near the C-terminus of the A1 subunit, and at Arg562, bisecting the A2 subunit, the proteolysis abolishes the cofactor activity in the intrinsic factor Xase | Homo sapiens | ? | - |
? |  |
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