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Literature summary for 3.4.21.68 extracted from

  • Correa, F.; Gauberti, M.; Parcq, J.; Macrez, R.; Hommet, Y.; Obiang, P.; Hernangomez, M.; Montagne, A.; Liot, G.; Guaza, C.; Maubert, E.; Ali, C.; Vivien, D.; Docagne, F.
    Tissue plasminogen activator prevents white matter damage following stroke (2011), J. Exp. Med., 208, 1229-1242.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.68

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-
Mus musculus C57/BL6
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
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brain
-
 Homo sapiens
-
cerebral grey matter
-
 Mus musculus
-
cerebral grey matter
-
 Homo sapiens
-
corpus callosum
-
 Mus musculus
-
corpus callosum
-
 Homo sapiens
-
oligodendrocyte
-
 Mus musculus
-
oligodendrocyte
-
 Homo sapiens
-
white matter
-
 Mus musculus
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white matter
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
 Mus musculus
Tissue plasminogen activator
-
 Homo sapiens
tPA
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 Mus musculus
tPA
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function mechanism of action of tPA on oligodendrocyte survival and on the extent of white matter lesions in stroke, overview. tPA protects oligodendrocytes from apoptosis through an unexpected cytokine-like effect by the virtue of its epidermal growth factor-like domain, and tPA protects white matter from stroke-induced lesions. Aging differentially influences gray and white matter susceptibility to stroke. tPA, via extracellular regulated kinase 1/2 and Akt intracellular pathways, regulates the balance between proand antiapoptotic factors and reduces the activity of caspase 3 Mus musculus
physiological function mechanism of action of tPA on oligodendrocyte survival and on the extent of white matter lesions in stroke, overview. tPA protects oligodendrocytes from apoptosis through an unexpected cytokine-like effect by the virtue of its epidermal growth factor-like domain, and tPA protects white matter from stroke-induced lesions. Aging differentially influences gray and white matter susceptibility to stroke. tPA, via extracellular regulated kinase 1/2 and Akt intracellular pathways, regulates the balance between proand antiapoptotic factors and reduces the activity of caspase 3 Homo sapiens