Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.68 extracted from

  • Ohki, M.; Ohki, Y.; Ishihara, M.; Nishida, C.; Tashiro, Y.; Akiyama, H.; Komiyama, H.; Lund, L.R.; Nitta, A.; Yamada, K.; Zhu, Z.; Ogawa, H.; Yagita, H.; Okumura, K.; Nakauchi, H.; Werb, Z.; Heissig, B.; Hattori, K.
    Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration (2010), Blood, 115, 4302-4312.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.68

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Mus musculus C57BL/6
-
-
-

Synonyms

Synonyms Comment Organism
tissue type plasminogen activator
-
 Mus musculus
tPA
-
 Mus musculus

General Information

General Information Comment Organism
physiological function tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration. Serpin-resistant form of tPA expands the myeloid cell pool and mobilizes CD45+ CD11b+ proangiogenic, myeloid cells, by activating the extracellular proteases matrix metalloproteinase-9 and plasmin, a process dependent on vascular endothelial growth factor-A and Kit ligand signaling. tPA improves the incorporation of CD11b+ cells into ischemic tissues and increases expression of neoangiogenesis-related genes, including VEGF-A, kinetics and mechanism, overview. tPA can induce cell migration by binding to CD11b and degrading fibrin. Batroxobin, a drug that reduces circulating fibrinogen, prevents the tPA-mediated WBC and CD11b+ cell increase. Inhibition of VEGF signaling suppresses tPA-induced neovascularization in a model of hind limb ischemia Mus musculus