Literature summary for 3.4.21.68 extracted from

Iyer, A.M.; Zurolo, E.; Boer, K.; Baayen, J.C.; Giangaspero, F.; Arcella, A.; Di Gennaro, G.C.; Esposito, V.; Spliet, W.G.; van Rijen, P.C.; Troost, D.; Gorter, J.A.; Aronica, E.
Tissue plasminogen activator and urokinase plasminogen activator in human epileptogenic pathologies (2010), Neuroscience, 167, 929-945.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	tPA is induced in epilepsy by a mechanism underlying seizure activity. Expression and cellular distribution of tPA in several epileptogenic pathologies, including hippocampal sclerosis, and developmental glioneuronal lesions, such as focal cortical dysplasia, cortical tubers in patients with the tuberous sclerosis complex and in gangliogliomas, using immuno-cytochemical, western blot and real-time quantitative PCR analysis, overview. The analysis shows increased expression within the epileptogenic lesions compared to control specimens in both glial and neuronal cells. Quantitative real-time quantitative PCR analysis of tPA mRNA expression, overview	Homo sapiens	-
brain cortex	-	Homo sapiens	-
hippocampus	-	Homo sapiens	-
neuron	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
Tissue plasminogen activator	-	Homo sapiens
tPA	-	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	tPA is induced in epilepsy by a mechanism underlying seizure activity. Expression and cellular distribution of tPA in several epileptogenic pathologies, including hippocampal sclerosis, and developmental glioneuronal lesions, such as focal cortical dysplasia, cortical tubers in patients with the tuberous sclerosis complex and in gangliogliomas, using immuno-cytochemical, western blot and real-time quantitative PCR analysis, overview	up

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Release 2023.1 (January 2023)