Application | Comment | Organism |
---|---|---|
medicine | it is used clinically to dissolve | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
vesicle | - |
Mus musculus | 31982 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | Mus musculus | - |
plasmin + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | - |
Mus musculus | - |
brain | - |
Mus musculus | - |
cerebellar Purkinje cell | - |
Mus musculus | - |
corpus striatum | - |
Mus musculus | - |
hippocampus | - |
Mus musculus | - |
prefrontal cortex | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | - |
Mus musculus | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
Mus musculus |
tPA | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient -/- mice, the tPA-/- mice demonstrate an enhanced tendency to actively explore and engage in behaviors involving more exposure in the open field, O-maze and elevated plus maze | Mus musculus |
physiological function | serine protease, which converts plasminogen into plasmin, which in turn degrades fibrin and other extracellular matrix components, tPA plays an important role in the processes of learning and memory, demonstrated at the level of behavior and synaptic plasticity, role in neurodegeneration | Mus musculus |