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Literature summary for 3.4.21.68 extracted from

  • Pothakos, K.; Robinson, J.K.; Gravanis, I.; Marsteller, D.A.; Dewey, S.L.; Tsirka, S.E.
    Decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient (tPA-/-) mice (2010), Brain Res., 1326, 135-142.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.68

Application

Application Comment Organism
medicine it is used clinically to dissolve Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
vesicle
-
 Mus musculus 31982
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
plasminogen + H2O Mus musculus
-
 plasmin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala
-
 Mus musculus
-
brain
-
 Mus musculus
-
cerebellar Purkinje cell
-
 Mus musculus
-
corpus striatum
-
 Mus musculus
-
hippocampus
-
 Mus musculus
-
prefrontal cortex
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Mus musculus plasmin + ?
-
 ?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
 Mus musculus
tPA
-
 Mus musculus

General Information

General Information Comment Organism
malfunction decreased serotonin levels associated with behavioral disinhibition in tissue plasminogen activator deficient -/- mice, the tPA-/- mice demonstrate an enhanced tendency to actively explore and engage in behaviors involving more exposure in the open field, O-maze and elevated plus maze Mus musculus
physiological function serine protease, which converts plasminogen into plasmin, which in turn degrades fibrin and other extracellular matrix components, tPA plays an important role in the processes of learning and memory, demonstrated at the level of behavior and synaptic plasticity, role in neurodegeneration Mus musculus