Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in mice subjected to acute restraint stress, tPA activity is rapidly up-regulated in the amygdala | Mus musculus | |
statins | can induce tPA and inhibits plasminogen activator inhibitor-1 | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | tPA-plasmin pathway dysfunction may play a role in the link between major depressive disorder and cardiovascular disease. Agents that modulate tPA-plasminogen activity may be potential drugs for the treatment of patients with both major depressive disorder and cardiovascular disease | Mus musculus |
medicine | tPA-plasmin pathway dysfunction may play a role in the link between major depressive disorder and cardiovascular disease. Agents that modulate tPA-plasminogen activity may be potential drugs for the treatment of patients with both major depressive disorder and cardiovascular disease | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | mice in which the tPA gene has been disrupted do not show anxiety after repeated stress | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
plasminogen activator inhibitor-1 | is the major inhibitor of tPA-plasminogen signaling. Evidence for an association between plasminogen activator inhibitor-1 and cardiovascular disease pathogenesis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | - |
Mus musculus | - |
blood | functions as a thrombolytic enzyme | Homo sapiens | - |
brain | promotes events associated with synaptic plasticity and cell death, such as neurodegeneration and seizures | Homo sapiens | - |
hippocampus | tPA-plasmin system is abundantly expressed | Homo sapiens | - |
plasma | patients with depression show significantly lower plasma tPA concentrations than normal persons | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
plasminogen + H2O | the tPA plasminogen proteolytic cascade is involved in the cleavage of probrain-derived neurotrophic factor to brain-derived neurotrophic factor, by which the direction of brain-derived neurotrophic factor action is controlled. Brain-derived neurotrophic factor is important for the pathogenesis of major depressive disorder | Homo sapiens | plasmin + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
Mus musculus |
Tissue plasminogen activator | - |
Homo sapiens |
tPA | - |
Mus musculus |
tPA | - |
Homo sapiens |