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Literature summary for 3.4.21.68 extracted from

  • Hou, S.J.; Yen, F.C.; Tsai, S.J.
    Is dysfunction of the tissue plasminogen activator (tPA)-plasmin pathway a link between major depression and cardiovascular disease? (2009), Med. Hypotheses, 72, 166-168.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information in mice subjected to acute restraint stress, tPA activity is rapidly up-regulated in the amygdala Mus musculus
statins can induce tPA and inhibits plasminogen activator inhibitor-1 Homo sapiens

Application

Application Comment Organism
medicine tPA-plasmin pathway dysfunction may play a role in the link between major depressive disorder and cardiovascular disease. Agents that modulate tPA-plasminogen activity may be potential drugs for the treatment of patients with both major depressive disorder and cardiovascular disease Mus musculus
medicine tPA-plasmin pathway dysfunction may play a role in the link between major depressive disorder and cardiovascular disease. Agents that modulate tPA-plasminogen activity may be potential drugs for the treatment of patients with both major depressive disorder and cardiovascular disease Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information mice in which the tPA gene has been disrupted do not show anxiety after repeated stress Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
plasminogen activator inhibitor-1 is the major inhibitor of tPA-plasminogen signaling. Evidence for an association between plasminogen activator inhibitor-1 and cardiovascular disease pathogenesis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amygdala
-
Mus musculus
-
blood functions as a thrombolytic enzyme Homo sapiens
-
brain promotes events associated with synaptic plasticity and cell death, such as neurodegeneration and seizures Homo sapiens
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hippocampus tPA-plasmin system is abundantly expressed Homo sapiens
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plasma patients with depression show significantly lower plasma tPA concentrations than normal persons Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O the tPA plasminogen proteolytic cascade is involved in the cleavage of probrain-derived neurotrophic factor to brain-derived neurotrophic factor, by which the direction of brain-derived neurotrophic factor action is controlled. Brain-derived neurotrophic factor is important for the pathogenesis of major depressive disorder Homo sapiens plasmin + ?
-
?

Synonyms

Synonyms Comment Organism
Tissue plasminogen activator
-
Mus musculus
Tissue plasminogen activator
-
Homo sapiens
tPA
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Mus musculus
tPA
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Homo sapiens