Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bradykinin | endothelium-dependent vasodilator that stimulates the release of t-PA. Causes a dose-dependent increase in plasma t-PA antigen and activity concentrations in the infused arm of both pregnant and non-pregnant women. The increase in t-PA activity is greater in the nonpregnant women. Bradykinin increases the net release of t-PA antigen and activity in both pregnant women and non-pregnant women. Both net release of active t-PA and plasma t-PA/plasminogen activator inhibitor type 1 ratios are markedly reduced in pregnant women | Homo sapiens | |
additional information | nitroprusside, which is an endothelium-independent vasodilator, does not stimulate release of t-PA | Homo sapiens |
Application | Comment | Organism |
---|---|---|
medicine | pregnancy is associated with major perturbations of endogenous fibrinolytic capacity with an overwhelming increase in plasma plasminogen activator inhibitor type 1 concentrations and an inadequate release of active t-PA, i.e., these prothrombotic effects may, in part, explain the increased risk of arterial and venous thrombosis in pregnant women | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
plasminogen activator inhibitor type 1 | pregnant women have higher plasma plasminogen activator inhibitor type 1 antigen concentrations that result in lower basal t-PA/plasminogen activator inhibitor type 1 ratios and plasma t-PA activity concentrations | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | - |
Homo sapiens | - |
plasma | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
t-PA | - |
Homo sapiens |
Tissue plasminogen activator | - |
Homo sapiens |