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Literature summary for 3.4.21.68 extracted from

  • Hu, K.; Lin, L.; Tan, X.; Yang, J.; Bu, G.; Mars, W.M.; Liu, Y.
    tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis (2008), J. Am. Soc. Nephrol., 19, 503-514.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
additional information tPA can act as a cytokine, executing its cytoprotective actions via activation of a survival signaling hierarchy in interstitial fibroblasts Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information compared with wild-type, apoptosis of interstitial myofibroblasts is increased in tPA-/- mice after obstructive injury Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens
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Mus musculus
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information tPA is a survival factor that prevents renal interstitial fibroblasts (cell line NRK-49F) and myofibroblasts from apoptosis induced by staurosporine and oxidative stress through an LRP-1-, Erk1/2-, p90RSK-, and Bad-dependent mechanism. Antiapoptotic effect of tPA is independent of its protease activity Homo sapiens ?
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?

Synonyms

Synonyms Comment Organism
Tissue-type plasminogen activator
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Mus musculus
Tissue-type plasminogen activator
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Homo sapiens
tPA
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Mus musculus
tPA
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Homo sapiens