Activating Compound | Comment | Organism | Structure |
---|---|---|---|
epinephrine | intrabrachial infusion of epinephrine (0.1 to 0.3 microg/100 ml per minute) induces greater t-PA release in normotensive subjects as compared with essential hypertensive patients | Homo sapiens | |
isoproterenol | intrabrachial isoproterenol (0.03 mcirog/100 ml per minute) induces a significant increase in t-PA release, an effect blunted by NG-monomethyl-L-arginine | Homo sapiens | |
additional information | adrenergic-induced t-PA release is mediated by beta-adrenoreceptors via a mechanism involving the NO pathway. No significant difference in net t-PA release after ouabain infusion. No significant increase in t-PA release during sodium nitroprusside infusion | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | inhibition of NO synthase with NG-monomethyl-L-arginine (100 microg/100 ml per minute) infusion blunts epinephrine-induced t-PA release in normotensive subjects but not in essential hypertensive patients. In normotensive subjects, t-PA release by epinephrine is not affected by phentolamine coinfusion | Homo sapiens | |
propanolol | in normotensive subjects, t-PA release by epinephrine is abolished in the presence of propanolol (10 microg/100 ml per minute). In essential hypertensive patients, the response to isoproterenol is impaired as compared with normotensive subjects and is unaffected by NG-monomethyl-L-arginine coinfusion | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelial cell | arterial and venous concentrations of t-PA are significantly lower in hypertensive patients than in normotensive subjects | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
t-PA | - |
Homo sapiens |
Tissue-type plasminogen activator | - |
Homo sapiens |