Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | neither human albumin nor control human IgG affect tPA-dependent plasminogen activation | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | stimulation of tPA-mediated plasminogen activity by beta2-glycoprotein I is inhibited by monoclonal anti-beta2GPI antibodies as well as by anti-beta2GPI antibodies from patients with antiphospholipid syndrome. Binding to beta2-glycoprotein I is competitively inhibited by fluid-phase tPA | Homo sapiens | |
NaCl | high concentrations inhibit the binding of beta2-glycoprotein I to tPA | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000464 | - |
plasminogen | in the presence of beta2-glycoprotein I | Homo sapiens | |
0.0003148 | - |
plasminogen | in the presence of beta2-glycoprotein I domain V | Homo sapiens | |
0.0004538 | - |
plasminogen | in the presence of bovine serum albumin | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
plasma | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-Val-Leu-Lys-7-amido-4-methylcoumarin + H2O | - |
Homo sapiens | ? | - |
? | |
Glu-plasminogen + H2O | - |
Homo sapiens | plasmin + ? | - |
? | |
glutaryl-Gly-7-Arg-amido-4-methylcoumarin + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Tissue plasminogen activator | - |
Homo sapiens |
tPA | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.1149 | - |
plasminogen | in the presence of bovine serum albumin | Homo sapiens | |
0.231 | - |
plasminogen | in the presence of beta2-glycoprotein I | Homo sapiens | |
0.4718 | - |
plasminogen | in the presence of beta2-glycoprotein I domain V | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | native and recombinant beta2-glycoprotein I or its domain V stimulate tPA-dependent plasminogen activation in a concentration-dependent manner. Beta2-glycoprotein I binds tPA with high affinity (Kd =20 nmol), stimulates tPA amidolytic activity, and causes an overall 20fold increase in the catalytic efficiency (kcat/Km) of tPA-mediated conversion of Glu-plasminogen to plasmin | Homo sapiens |