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Literature summary for 3.4.21.68 extracted from
- IL-1alpha is a potent stimulator of keratinocyte tissue plasminogen activator expression and regulated by TGF-beta1 (2008), Arch. Dermatol. Res., 300, 185-193.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| interleukin-1alpha | increases mRNA and protein expression of tPA in a time- and dose-dependent manner. Maximal stimulation at 72 h and 100 U/ml | Mus musculus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | tPA generation in wound epidermis is at least partially controlled by changes in local interleukin-1alpha activity | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| transforming growth factor-beta1 | partially inhibits interleukin-1alpha induced expression of tPA mRNA in a dose-dependent manner, maximal inhibition at 60 ng/ml | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| keratinocyte | present in keratinocytes at the leading edge of the wound | Mus musculus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Tissue plasminogen activator | - |
Mus musculus |
| tPA | - |
Mus musculus |
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