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Literature summary for 3.4.21.68 extracted from
- Thrombolysis vs. bleeding from hemostatic sites by a prourokinase mutant compared with tissue plasminogen activator (2006), J. Thromb. Haemost., 4, 1559-1565.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | dogs with femoral artery thrombosis are given either M5, a single site mutant of prourkinase or tPA by i.v. infusion. Thrombolysis is comparably effective by both activators. Blood loss is 10-fold higher with t-PA than with M5 and occurred at more multiple sites. This effect is postulated to be related to differences in the mechanism of plasminogen activation by t-PA and M5 in which the latter is promoted by degraded rather than intact (hemostatic) fibrin | Canis lupus familiaris |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Canis lupus familiaris | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| tPA | - |
Canis lupus familiaris |
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Release 2023.1 (January 2023)
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