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Literature summary for 3.4.21.68 extracted from

  • Hurtado, M.; Lozano, J.J.; Castellanos, E.; Lopez-Fernandez, L.A.; Harshman, K.; Martinez-A, C.; Ortiz, A.R.; Thomson, T.M.; Paciucci, R.
    Activation of the epidermal growth factor signalling pathway by tissue plasminogen activator in pancreas cancer cells (2007), Gut, 56, 1266-1274.
    View publication on PubMedView publication on EuropePMC
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Protein Variants

Protein Variants Comment Organism
additional information it is shown that tPA induces a rapid and transient phosphorylation of the epidermal growth factor receptor. Specific EGFR kinase inhibitors abolish the tPA induced phosphorylation of the extracellular activated kinases 1/2 and cell proliferation. Mitogenic activity of tPA is inhibited by siRNA depletion of EGFR, thus confirming the involvement of this receptor in tPA triggered signalling. It is shown that the signalling and mitogenic effects of tPA require its proteolytic activity, the activity of the metalloprotease-9 and active heparin binding-epidermal growth factor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
pancreatic cancer cell line PANC1 Homo sapiens
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Synonyms

Synonyms Comment Organism
tPA
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 Homo sapiens