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Literature summary for 3.4.21.68 extracted from

  • Coombs, G.S.; Bergstrom, R.C.; Madison, E.L.; Corey, D.R.
    Directing sequence-specific proteolysis to new targets. The influence of loop size and target sequence on selective proteolysis by tissue-type plasminogen activator and urokinase-type plasminogen activator (1998), J. Biol. Chem., 273, 4323-4328.
    View publication on PubMed
Search for more literature for 3.4.21.68

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0089
-
 [SNase]-PQRGRSAG pH 7.4, 37°C Homo sapiens
0.0093
-
 [SNase]-PGPFGRSAGG pH 7.4, 37°C Homo sapiens
0.0099
-
 [SNase]-PGPFGRSAG pH 7.4, 37°C Homo sapiens
0.0099
-
 [SNase]-PPFGRSAG pH 7.4, 37°C Homo sapiens
0.017
-
 [SNase]-PGSGRSAG pH 7.4, 37°C Homo sapiens
0.018
-
 [SNase]-PHYGRSGG pH 7.4, 37°C Homo sapiens
0.079
-
 [SNase]-PFGRSAG pH 7.4, 37°C Homo sapiens
0.14
-
 [SNase]-PFGRSA pH 7.4, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 human
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
plasminogen + H2O
-
 Homo sapiens plasmin + ?
-
 ?
[SNase]-PFGRSA + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PFGR + [SNase]-Ser-Ala
-
 ?
[SNase]-PFGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PFGR + [SNase]-Ser-Ala-Gly
-
 ?
[SNase]-PGPFGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PGPFGR + [SNase]-Ser-Ala-Gly
-
 ?
[SNase]-PGPFGRSAGG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PGPFGR + [SNase]-Ser-Ala-Gly-Gly
-
 ?
[SNase]-PGSGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PGSGR + [SNase]-Ser-Ala-Gly
-
 ?
[SNase]-PHYGRSGG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PHYGR + [SNase]-Ser-Gly-Gly
-
 ?
[SNase]-PPFGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PPFGR + [SNase]-Ser-Ala-Gly
-
 ?
[SNase]-PQRGRSAG + H2O staphylococcal nuclease with substitutions for amino acids 44-51 Homo sapiens [SNase]-PQRGR + [SNase]-Ser-Ala-Gly
-
 ?

Synonyms

Synonyms Comment Organism
tissue type plasminogen activator
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0041
-
 [SNase]-PFGRSA pH 7.4, 37°C Homo sapiens
0.006
-
 [SNase]-PQRGRSAG pH 7.4, 37°C Homo sapiens
0.0075
-
 [SNase]-PGPFGRSAG pH 7.4, 37°C Homo sapiens
0.01
-
 [SNase]-PGPFGRSAGG pH 7.4, 37°C Homo sapiens
0.011
-
 [SNase]-PPFGRSAG pH 7.4, 37°C Homo sapiens
0.012
-
 [SNase]-PHYGRSGG pH 7.4, 37°C Homo sapiens
0.018
-
 [SNase]-PFGRSAG pH 7.4, 37°C Homo sapiens