Crystallization (Comment) | Organism |
---|---|
crystal structure shows that an unusual extended disulfhide-tethered loop functions as an exosite, mediating effective enzyme-substrate interactions. The disulphide bond and Tyr92, which is located at the exposed end of the loop, is functionally important | Dichelobacter nodosus |
Protein Variants | Comment | Organism |
---|---|---|
DELTA83-99 | truncation mutant is not functional | Dichelobacter nodosus |
Y92A | mutant shows decreased elastin degradation | Dichelobacter nodosus |
Y92D | mutant shows decreased elastin degradation | Dichelobacter nodosus |
Y92F | mutant shows increased elastin degradation | Dichelobacter nodosus |
Y92L | mutant shows decreased elastin degradation | Dichelobacter nodosus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Dichelobacter nodosus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta subunit of haemoglobin + H2O | - |
Dichelobacter nodosus | ? | - |
? | |
Elastin + H2O | - |
Dichelobacter nodosus | ? | - |
? | |
serum albumin + H2O | - |
Dichelobacter nodosus | ? | - |
? | |
type I keratin + H2O | - |
Dichelobacter nodosus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
subtilisin-like protease AprV2 | - |
Dichelobacter nodosus |
General Information | Comment | Organism |
---|---|---|
malfunction | using a protease mutant of Dichelobacter nodosus it is shown in a sheep virulence model that AprV2 is required for virulence | Dichelobacter nodosus |