Literature summary for 3.4.21.62 extracted from

Doswald, S.; Estermann, H.; Kupfer, E.; Stadler, H.; Walther, W.; Weisbrod, T.; Wirz, B.; Wostl, W.
Large scale preparation of chiral building blocks for the P3 site of renin inhibitors (1994), Bioorg. Med. Chem., 2, 403-410.

Search for more literature for 3.4.21.62

Application

Application	Comment	Organism
synthesis	production of (R)-(2-methylpropyl)butanedioic acid 4-ethyl ester	Bacillus sp. (in: Bacteria)
synthesis	production of (R)-2-benzyl-3-[[1-methyl-1-((morpholin-4-yl)-carbonyl)ehtyl]sulfonyl]propionic acid-ethyl ester, which was prepared as an intermediate for the renin inhibitors ciprokiren and remikiren	Bacillus licheniformis
synthesis	production of (S)-2-benzyl-3-(tert-butylsulfonyl)propionic acid, which was prepared as an intermediate for the renin inhibitor remikiren	Bacillus licheniformis

Organism

Organism	UniProt	Comment	Textmining
Bacillus licheniformis	-	-	-
Bacillus sp. (in: Bacteria)	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(R,S)-2-benzyl-3-(tert-butylsulfonyl)propionic acid + H2O	-	Bacillus licheniformis	(R)-2-benzyl-3-(tert-butylsulfonyl)propionic ethyl ester + (S)-2-benzyl-3-(tert-butylsulfonyl)propionic acid + ethanol	-	?
(R,S)-2-benzyl-3-[[1-methyl-1-((morpholin-4-yl)-carbonyl)ethyl]sulfonyl]propionic acid + H2O	-	Bacillus licheniformis	(S)-2-benzyl-3-[[1-methyl-1-((morpholin-4-yl)-carbonyl)ethyl]sulfonyl]propionic acid + (R)-2-benzyl-3-[[1-methyl-1-((morpholin-4-yl)-carbonyl)ethyl]sulfonyl]propionic acid-ethyl ester + ethanol	-	?
(R/S)-(2-methylpropyl)butanedioic acid diethyl ester + H2O	-	Bacillus sp. (in: Bacteria)	(S)-(2-methylpropyl)butanedioic acid diethyl ester + (R)-(2-methylpropyl)butanedioic acid 4-ethyl ester + ethanol	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
24	-	-	Bacillus sp. (in: Bacteria)
40	-	-	Bacillus licheniformis

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	-	Bacillus licheniformis
7.5	-	.8.5	Bacillus licheniformis
8.5	-	-	Bacillus sp. (in: Bacteria)

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)