Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
low density lipoprotein receptor-related protein 1 + H2O | Cricetulus griseus | degradation | ? | - |
? | |
low density lipoprotein receptor-related protein 1 + H2O | Homo sapiens | degradation | ? | - |
? | |
low density lipoprotein receptor-related protein 1 + H2O | Mus musculus | degradation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cricetulus griseus | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | Q80W65 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
B16-F1 cell | - |
Mus musculus | - |
B16-F10 cell | - |
Mus musculus | - |
CHO-13-5-1 cell | - |
Cricetulus griseus | - |
CHO-A7 cell | - |
Cricetulus griseus | - |
CHO-K1 cell | - |
Cricetulus griseus | - |
HEK-293 cell | - |
Homo sapiens | - |
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Mus musculus | - |
melanoma cell | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
low density lipoprotein receptor-related protein 1 + H2O | degradation | Cricetulus griseus | ? | - |
? | |
low density lipoprotein receptor-related protein 1 + H2O | degradation | Homo sapiens | ? | - |
? | |
low density lipoprotein receptor-related protein 1 + H2O | degradation | Mus musculus | ? | - |
? | |
low density lipoprotein receptor-related protein 1 + H2O | the enzyme acts on the extracellular domain of the receptor molecule | Cricetulus griseus | ? | - |
? | |
low density lipoprotein receptor-related protein 1 + H2O | the enzyme acts on the extracellular domain of the receptor molecule | Homo sapiens | ? | - |
? | |
low density lipoprotein receptor-related protein 1 + H2O | the enzyme acts on the extracellular domain of the receptor molecule | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PCSK9 | - |
Cricetulus griseus |
PCSK9 | - |
Homo sapiens |
PCSK9 | - |
Mus musculus |
proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9 | - |
Cricetulus griseus |
proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9 | - |
Homo sapiens |
proprotein convertase subtilisin/kexin type 9 (PCSK9)Proprotein convertase subtilisin/kexin type 9 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | proprotein convertase subtilisin/kexin 9 enhances the degradation of the LDL receptor in endosomes/lysosomes, resulting in increased circulating LDLc. The enzyme can also mediate the degradation of LDL receptor lacking its cytosolic tail, the transmembrane-domain of the receptor is not involved, but a lysosomal-targeting factor, overview. Role for the enzyme in enhancing tumor metastasis, consequences of enzyme inhibition for lowering LDLc and tumor metastasis | Homo sapiens |
physiological function | proprotein convertase subtilisin/kexin 9 enhances the degradation of the LDL receptor in endosomes/lysosomes, resulting in increased circulating LDLc. The enzyme can also mediate the degradation of LDL receptor lacking its cytosolic tail, the transmembrane-domain of the receptor is not involved, but a lysosomal-targeting factor.overview. The LDL receptor is insensitive to the enzyme in murine B16F1 melanoma cells, but the enzyme is able to induce degradation of the low density lipoprotein receptor-related protein 1, suggesting distinct targeting mechanisms for these receptors. Role for the enzyme in enhancing tumor metastasis | Mus musculus |
physiological function | proprotein convertase subtilisin/kexin 9 enhances the degradation of the LDL receptor in endosomes/lysosomes, resulting in increased circulating LDLc. The enzyme is capable of acting upon the LDL receptor in CHO 13-5-1 cells lacking LRP-1. It also acts on LRP-1 in the absence of the LDL receptor in CHO-A7 cells, where re-introduction of the LDL receptor leads to reduced enzyme-mediated degradation of LRP-1 | Cricetulus griseus |