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Literature summary for 3.4.21.61 extracted from

  • Kwakernaak, A.J.; Lambert, G.; Dullaart, R.P.
    Plasma proprotein convertase subtilisin-kexin type 9 is predominantly related to intermediate density lipoproteins (2014), Clin. Biochem., 47, 679-682.
    View publication on PubMed

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
low density lipoprotein receptor + H2O Homo sapiens
-
?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q8NBP7
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-

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
low density lipoprotein receptor + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
PCSK9
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Homo sapiens
plasma proprotein convertase subtilisin-kexin type 9
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Homo sapiens

General Information

General Information Comment Organism
physiological function proprotein convertase subtilisin-kexin type 9 is a key regulator of low density lipoprotein receptor processing, and affects especially intermediate density lipoproteins. The enzyme pathway may affect plasma triglycerides via effects on the metabolism of triglyceriderich LDL particles Homo sapiens