Application | Comment | Organism |
---|---|---|
drug development | anti-PCSK9 antibodies may be effective therapeutics for treating hypercholesterolemia | Mus musculus |
drug development | anti-PCSK9 antibodies may be effective therapeutics for treating hypercholesterolemia | Macaca fascicularis |
drug development | anti-PCSK9 antibodies may be effective therapeutics for treating hypercholesterolemia | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
D374Y | gain-of-function mutant, human monoclonal antibody mAb1 also blocks binding of PCSK9 to low density lipoprotein receptor in the mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | human monoclonal antibody against PCSK9, mAb1, inhibits PCSK9 binding to the low density lipoprotein receptor and attenuates PCSK9-mediated reduction in low density lipoprotein receptor protein levels, thereby increasing low density lipoprotein uptake. A combination of mAb1 with a statin increases low density lipoprotein receptor levels in Hep-G2 cells more than either treatment alone | Homo sapiens | |
additional information | human monoclonal antibody against PCSK9, mAb1, inhibits PCSK9 binding to the low density lipoprotein receptor and attenuates PCSK9-mediated reduction in low density lipoprotein receptor protein levels, thereby increasing low density lipoprotein uptake. A single injection of mAb1 reduces serum LDL-C by 80%, and a significant decrease is maintained for 10 days | Macaca fascicularis | |
additional information | human monoclonal antibody against PCSK9, mAb1, inhibits PCSK9 binding to the low density lipoprotein receptor and attenuates PCSK9-mediated reduction in low density lipoprotein receptor protein levels, thereby increasing low density lipoprotein uptake. In wild-type mice, mAb1 increases hepatic low density lipoprotein receptor protein levels ca. 2fold and lowers total serum cholesterol by up to 36% | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NBP7 | - |
- |
Macaca fascicularis | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
low density lipoprotein receptor + H2O | - |
Mus musculus | ? | - |
? | |
low density lipoprotein receptor + H2O | - |
Macaca fascicularis | ? | - |
? | |
low density lipoprotein receptor + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PCSK9 | - |
Mus musculus |
PCSK9 | - |
Macaca fascicularis |
PCSK9 | - |
Homo sapiens |
proprotein convertase subtilisin/kexin type 9 | - |
Mus musculus |
proprotein convertase subtilisin/kexin type 9 | - |
Macaca fascicularis |
proprotein convertase subtilisin/kexin type 9 | - |
Homo sapiens |