Literature summary for 3.4.21.61 extracted from

Lan, H.; Pang, L.; Smith, M.M.; Levitan, D.; Ding, W.; Liu, L.; Shan, L.; Shah, V.V.; Laverty, M.; Arreaza, G.; Zhang, Q.; Murgolo, N.J.; Hernandez, M.; Greene, J.R.; Gustafson, E.L.; Bayne, M.L.; Davis, H.R.; Hedrick, J.A.
Proprotein convertase subtilisin/kexin type 9 (PCSK9) affects gene expression pathways beyond cholesterol metabolism in liver cells (2010), J. Cell. Physiol., 224, 273-281.

Search for more literature for 3.4.21.61

Cloned(Commentary)

Cloned (Comment)	Organism
wild type and mutant D374Y-FLAG expressed in Hep-G2 cells	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
D374Y	gain-of-function PCSK9, has a greater activity reducing low density lipoprotein receptor in Hep-G2 cells	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q8NBP7	-	-

Purification (Commentary)

Purification (Comment)	Organism
at 4°C by binding to anti-FLAG M2 affinity gel	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
low density lipoprotein receptor + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
PCSK9	-	Homo sapiens
proprotein convertase subtilisin/kexin type 9	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	PCSK9-induced upregulation of cholesterol biosynthesis genes results from intracellular cholesterol starvation. PCSK9 affects metabolic pathways beyond cholesterol metabolism in Hep-G2 cells. Pathways that are presumably regulated by PCSK9 and are independent of its effects on cholesterol uptake include protein ubiquitination, xenobiotic metabolism, cell cycle, and inflammation and stress response	Homo sapiens

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Release 2023.1 (January 2023)