Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q8NBP7 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | Caco-2/15 cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
low-density lipoprotein receptor | PCSK9 posttranslationally promotes the degradation of the low-density lipoprotein receptor | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PCSK9 | - |
Homo sapiens |
proprotein convertase subtilisin/kexin type 9 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | cholesterol (0.1 mM) solubilized in albumin or micelles significantly downregulates PCSK9 gene (30%) and protein expression (50%) in Caco-2/15 cells. Cells treated with 25-hydroxycholesterol (0.05 mM) also display significant reduction in PCSK9 gene (37%) and protein (75%) expression. Addition of bile acids taurocholate and deoxycholate to the apical culture medium lowers PCSK9 gene expression (25%) and raises PCSK9 protein expression (30%), respectively, probably via the modulation of farnesoid X receptor | down |
Homo sapiens | amounts of PCSK9 mRNA and protein in Caco-2/15 cells are associated to the regulation of 3-hydroxy-3-methylglutaryl-CoA reductase and sterol regulatory element binding protein-2 that can transcriptionally activate PCSK9 via sterol-regulatory elements located in its proximal promoter region. Depletion of cholesterol content by hydroxypropyl-beta-cyclodextrin upregulates PCSK9 transcripts (20%) and protein mass (540%), in parallel with sterol regulatory element binding protein-2 protein levels | up |
General Information | Comment | Organism |
---|---|---|
physiological function | PCSK9 plays a role in the small intestine | Homo sapiens |