Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.4.21.61 extracted from

  • Jeong, H.J.; Lee, H.S.; Kim, K.S.; Kim, Y.K.; Yoon, D.; Park, S.W.
    Sterol-dependent regulation of proprotein convertase subtilisin/kexin type 9 expression by sterol-regulatory element binding protein-2 (2008), J. Lipid Res., 49, 399-409.
    View publication on PubMed
Search for more literature for 3.4.21.61

Activating Compound

Activating Compound Comment Organism Structure
lovastatin suppresses endogenous synthesis of sterols, increases both the proteins and mRNAs for PCSK9. 10 mM can reverse the increase of PCSK9 expression by lovastatin Homo sapiens
additional information depletion of sterols induces PCSK9 in a time-dependent manner Homo sapiens
additional information PCSK9 protein and mRNA are increased by refeeding after fasting. Supplementation with 2% cholesterol in the diet prevents the increase in PCSK9 Mus musculus
sodium mevalonate suppresses endogenous synthesis of sterols, PCSK9 is further increased Homo sapiens
sterol-regulatory element binding protein-1 dramatically increases the promoter activity of PCSK9 Homo sapiens
sterol-regulatory element binding protein-2 dramatically increases the promoter activity of PCSK9 Homo sapiens
sterol-regulatory element binding protein-2 predominantly mediates sterol-dependent regulation of PCSK9 in vivo Mus musculus

Application

Application Comment Organism
additional information expression of PCSK9 is regulated by sterol at the transcriptional level in HepG2 cells and that both SREBP-1 and SREBP-2 can transcriptionally activate PCSK9 via sterol-regulatory element in its proximal promoter region in vitro Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
into vector pET-21a(+) Homo sapiens
ligated into vector pCR2.1-Topo and subcloned into vector pET-21a(+) Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
additional information PCSK9 protein and mRNA are decreased significantly by fasting Mus musculus
sterol completely blocks increase in PCSK9 mRNA by lovastatin Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
 male C57B/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
 Homo sapiens
-
liver
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
PCSK9
-
 Mus musculus
PCSK9
-
 Homo sapiens
proprotein convertase subtilisin/kexin type 9
-
 Mus musculus
proprotein convertase subtilisin/kexin type 9
-
 Homo sapiens