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Literature summary for 3.4.21.61 extracted from

  • Heiman, M.G.; Engel, A.; Walter, P.
    The Golgi-resident protease Kex2 acts in conjunction with Prm1 to facilitate cell fusion during yeast mating (2007), J. Cell Biol., 176, 209-222.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.61

Application

Application Comment Organism
molecular biology role of Kex2 during cell fusion. Kex2 may promote cell fusion by proteolytically processing substrates that act in parallel to Prm1 as an alternative fusion machine, as cell wall components, or both Lachancea kluyveri

Protein Variants

Protein Variants Comment Organism
additional information Deltakex2 strongly enhances the cell fusion defect of Prm1-deficient mating pairs and causes a mild fusion defect in otherwise wild-type mating pairs. Deltakex2 and Deltakex1 fusion defects are suppressed by osmotic support. MATalpha/Deltakex2/Deltaprm1 mutant is sterile. A MATa/Deltakex2/Deltaprm1 mutant mates efficiently to a wild-type partner but poorly to a Deltaprm1 partner. Loss of KEX2 in the MATa partner alone decreases fusion by 15% compared with wild-type. Deltakex2 mutation produces a much stronger effect when placed in trans rather than in cis to the Deltaprm1 mutation. Severe cell wall defects in Deltakex2 mutant cells. Deltakex2 mutants produce cytoplasmic blebs embedded in the cell wall Lachancea kluyveri

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Lachancea kluyveri 5794
-

Organism

Organism UniProt Comment Textmining
Lachancea kluyveri
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Prm2
-
 Lachancea kluyveri ?
-
 ?
Ykl077w
-
 Lachancea kluyveri ?
-
 ?

Synonyms

Synonyms Comment Organism
Kex2
-
 Lachancea kluyveri