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BRENDA support

Literature summary for 3.4.21.6 extracted from

  • Scarborough, R.M.
    Coagulation factor Xa: the prothrombinase complex as an emerging therapeutic target for small molecule inhibitors (1998), J. Enzyme Inhib., 14, 15-25.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
additional information benzamidine functionally is a common theme in most classes of inhibitors, with many of the most potent compounds requiring two basic functional groups to afford potent inhibition. Reliance on this structural feature may afford difficulty in obtaining inhibitors with acceptable oral absorption and with sufficiant duration of action to qualify as clinical candidates for oral anticoagulant trials Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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