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Literature summary for 3.4.21.6 extracted from

  • de Candia, M.; Liantonio, F.; Carotti, A.; De Cristofaro, R.; Altomare, C.
    Fluorinated benzyloxyphenyl piperidine-4-carboxamides with dual function against thrombosis: inhibitors of factor Xa and platelet aggregation (2009), J. Med. Chem., 52, 1018-1028.
    View publication on PubMed
Search for more literature for 3.4.21.6

Inhibitors

Inhibitors Comment Organism Structure
1,1'-(benzene-1,4-diyldimethanediyl)bis(N,N-diethylpiperidine-3-carboxamide)
-
 Homo sapiens
1-carbamimidoyl-N-[3-[(4-fluorobenzyl)oxy]phenyl]piperidine-3-carboxamide
-
 Homo sapiens
1-carbamimidoyl-N-[3-[(4-fluorobenzyl)oxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
additional information synthesis of a series of benzyloxy anilides of nipecotic and isonipecotic acids, as inhibitors of ADP-induced platelet aggregation and the blood coagulation enzyme factor Xa Homo sapiens
N-(3-[[4'-(trifluoromethyl)biphenyl-4-yl]methoxy]phenyl)piperidine-4-carboxamide
-
 Homo sapiens
N-(4-butoxyphenyl)piperidine-3-carboxamide slight inhibition Homo sapiens
N-([3-(1,1'-biphenyl-4-yl)methoxy]phenyl)piperidine-4-carboxamide
-
 Homo sapiens
N-[3-(benzyloxy)phenyl]piperidine-3-carboxamide slight inhibition Homo sapiens
N-[3-(benzyloxy)phenyl]piperidine-4-carboxamide slight inhibition Homo sapiens
N-[3-(biphenyl-4-ylmethoxy)phenyl]-1-carbamimidoylpiperidine-3-carboxamide
-
 Homo sapiens
N-[3-(biphenyl-4-ylmethoxy)phenyl]-1-carbamimidoylpiperidine-4-carboxamide
-
 Homo sapiens
N-[3-(biphenyl-4-ylmethoxy)phenyl]piperidine-3-carboxamide
-
 Homo sapiens
N-[3-(biphenyl-4-ylmethoxy)phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(2',3'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(2',4',6'-trifluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(2',4'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(2',5'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(2',6'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(2'-fluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(3',4',5'-trifluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(3',5'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(3'-fluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(4'-fluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[3-[(4-fluorobenzyl)oxy]phenyl]piperidine-3-carboxamide
-
 Homo sapiens
N-[3-[(4-fluorobenzyl)oxy]phenyl]piperidine-4-carboxamide slight inhibition Homo sapiens
N-[4-(biphenyl-4-ylmethoxy)phenyl]piperidine-3-carboxamide slight inhibition Homo sapiens
N-[4-(biphenyl-4-ylmethoxy)phenyl]piperidine-4-carboxamide
-
 Homo sapiens
N-[4-[(4-fluorobenzyl)oxy]phenyl]piperidine-3-carboxamide slight inhibition Homo sapiens
N-[4-[(4-fluorobenzyl)oxy]phenyl]piperidine-4-carboxamide slight inhibition Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Z-D-Arg-Gly-Arg-4-nitroanilide + H2O
-
 Homo sapiens Z-D-Arg-Gly-Arg + 4-nitroaniline
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
FXa
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000057
-
 N-(3-[[4'-(trifluoromethyl)biphenyl-4-yl]methoxy]phenyl)piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.00013
-
 N-[3-[(3',5'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.000177
-
 N-[3-[(3'-fluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.000512
-
 N-[3-[(2',4'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.000548
-
 N-[3-[(2',3'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.000666
-
 N-[3-[(3',4',5'-trifluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.000767
-
 N-[3-[(2'-fluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.001
-
 N-[3-(biphenyl-4-ylmethoxy)phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.00127
-
 N-[3-[(2',5'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.00145
-
 N-[3-[(2',6'-difluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.002
-
 N-[3-(biphenyl-4-ylmethoxy)phenyl]-1-carbamimidoylpiperidine-3-carboxamide pH 8.0, 25°C Homo sapiens
0.0025
-
 N-[3-(biphenyl-4-ylmethoxy)phenyl]piperidine-3-carboxamide pH 8.0, 25°C Homo sapiens
0.00387
-
 N-[3-[(4'-fluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.0052
-
 N-[3-(biphenyl-4-ylmethoxy)phenyl]-1-carbamimidoylpiperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.00947
-
 N-[3-[(2',4',6'-trifluorobiphenyl-4-yl)methoxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.0338
-
 1-carbamimidoyl-N-[3-[(4-fluorobenzyl)oxy]phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.057
-
 1-carbamimidoyl-N-[3-[(4-fluorobenzyl)oxy]phenyl]piperidine-3-carboxamide pH 8.0, 25°C Homo sapiens
0.126
-
 N-[4-(biphenyl-4-ylmethoxy)phenyl]piperidine-4-carboxamide pH 8.0, 25°C Homo sapiens
0.26
-
 N-[3-[(4-fluorobenzyl)oxy]phenyl]piperidine-3-carboxamide pH 8.0, 25°C Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.045
-
 pH 8.0, 25°C Homo sapiens 1,1'-(benzene-1,4-diyldimethanediyl)bis(N,N-diethylpiperidine-3-carboxamide)
0.075
-
 pH 8.0, 25°C Homo sapiens N-(4-butoxyphenyl)piperidine-3-carboxamide