Literature summary for 3.4.21.6 extracted from

Kamath, P.; Krishnaswamy, S.
Fate of membrane-bound reactants and products during the activation of human prothrombin by prothrombinase (2008), J. Biol. Chem., 283, 30164-30173.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
prothrombin + H2O	at the physiological concentration of prothrombin, thrombin formation results in rapid release of the product into solution due to weak interaction between thrombin and the cleaved N-terminal F12 domain, of which fragment F1 plays an essential role in membrane binding. Thrombin itself interacts with poor affinity with the F12 domain	Homo sapiens	thrombin + thrombin N-terminal fragment F12	-	?

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Release 2023.1 (January 2023)