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Literature summary for 3.4.21.6 extracted from

  • Tanaka, M.; Arai, H.; Liu, N.; Nogaki, F.; Nomura, K.; Kasuno, K.; Oida, E.; Kita, T.; Ono, T.
    Role of coagulation factor Xa and protease-activated receptor 2 in human mesangial cell proliferation (2005), Kidney Int., 67, 2123-2133.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
DX-9065a inhibits factor Xa increased thymidine incorporation in mesangial cells, inhibits activation of extracellular regulated kinase in mesangial cells Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens factor Xa can induce mesangial cell proliferation through the activation of extracellular regulated kinase via protease-activated receptor 2 in mesangial cells. Protease-activated receptor 2 may play a crucial role in the cell proliferation induced by factor Xa ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information factor Xa can induce mesangial cell proliferation through the activation of extracellular regulated kinase via protease-activated receptor 2 in mesangial cells. Protease-activated receptor 2 may play a crucial role in the cell proliferation induced by factor Xa Homo sapiens ?
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 ?