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Literature summary for 3.4.21.6 extracted from

  • Gould, W.R.; Cladera, E.; Harris, M.S.; Zhang, E.; Narasimhan, L.; Thorn, J.M.; Leadley, R.J.
    Co-crystal structure and inhibition of factor Xa by PD0313052 identifies structurally stabilized active site residues of factor Xa and prothrombinase (2005), Biochemistry, 44, 9280-9289.
    View publication on PubMed
Search for more literature for 3.4.21.6

Crystallization (Commentary)

Crystallization (Comment) Organism
structure of factor Xa in complex with PD0313052 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
DX-9065a competitive, factor Xa Homo sapiens
PD0313052 slow, tight-binding mechanism, factor Xa; slow, tight-binding mechanism, prothrombinase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
FS-2765 + H2O FS-2765 is a fluorescent peptidyl substrate, factor Xa Homo sapiens ?
-
 ?
FS-2765 + H2O FS-2765 is a fluorescent peptidyl substrate, prothrombinase Homo sapiens ?
-
 ?
prothrombin + H2O prothrombinase Homo sapiens thrombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
prothrombinase complex consisting of factor Xa and Va Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00000017
-
 PD0313052 prothrombinase, substrate: FS-2765 Homo sapiens
0.00000025
-
 PD0313052 prothrombinase, substrate: prothrombin Homo sapiens
0.00000029
-
 PD0313052 substrate: FS-2765, factor Xa Homo sapiens
0.0000357
-
 DX-9065a substrate: FS-2765, factor Xa Homo sapiens