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Literature summary for 3.4.21.6 extracted from

  • Kalafatis, M.; Beck, D.O.; Mann, K.G.
    Structural requirements for expression of factor Va activity (2003), J. Biol. Chem., 278, 33550-33561.
    View publication on PubMed
Search for more literature for 3.4.21.6

Inhibitors

Inhibitors Comment Organism Structure
D13R
-
 Homo sapiens
factor Va peptide factor Va amino acid residues 697-709, i.e. D13R, competitive inhibition of prothrombinase activity with respect to prothrombin, inhibition mechanism Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens

Cofactor

Cofactor Comment Organism Structure
Factor VIIa human plasma factor V activated by thrombin, residues 1-709 and 1546-2196, required for catalytic activity in the prothrombinase complex activating prothrombin to thrombin Homo sapiens
factor VNN factor V cleaved by the venom of the snake Naja nigricollis nigricollis at Asp697, Asp1509, and Asp1514, 2 fragments of MW 100 and 80 kDa, 7% clotting activity compared to factor VIIa Homo sapiens
factor VNN/IIa factor VNN cleaved by alpha-thrombin at Arg1545, 48% clotting activity compared to factor VIIa Homo sapiens
factor VNN/RVV factor VNN cleaved by Russell's viper venom at Arg1545, 48% clotting activity compared to factor VIIa Homo sapiens
factor VRVV factor V cleaved by Russell's viper venom at Arg1018 and Arg1545, 2 fragments of MW 74 and 150 kDa, 102% clotting activity compared to factor VIIa Homo sapiens
additional information dissociation constants for binding to factor Xa for the factor Va variants at pH 7.4 and in presence of phospholipid vesicles containing phosphocholine and phosphatidylserine and Ca2+ Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0064
-
 D13R
-
 Homo sapiens